Sivu 1/1

Are Friedel Crafts Acylation ortho driven?

Lähetetty: Pe Heinä 06, 2018 18:17 pm
Kirjoittaja johntimber
Hi,

While I understand why para and ortho are more stable in EAS reactions, I don't understand why ortho seems to be the go to positions unless there's some crazy amount of steric hindrance. For example, when I was practicing friedel crafts acylation, almost all of them assumed that the electrophile would attach at the ortho position. Can someone clarify this for me?

Please help.

I didn't find the right solution from the Internet.

References:-
http://www.chemicalforums.com/index.php?topic=95980.0
Infographic design animation company

Thanks!